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New insights into glioma classification based on isocitrate dehydrogenase 1 and 2 gene status
Ichiyo Shibahara1, Yukihiko Sonoda, Masayuki Kanamori
1Department of Neurosurgery, Tohoku University School of Medicine, 1-1 Seiryo-machi Aoba-ku, Sendai 980-8575, Japan.
Abstract:
In glioma, mutations in the isocitrate dehydrogenase 1 and 2 (IDH1/2) genes have been receiving attention. IDH1/2 mutations are frequently found in grade II and III gliomas. These genetic alterations occur very early in gliomagenesis and strongly predict favorable outcome in patients with high-grade gliomas. Despite the evolution of studies on this topic, the underlying mechanism of the IDH1/2 mutations remains unknown. Here, we briefly review the current knowledge of IDH1/2 and discuss molecular diagnostics based on IDH1/2 gene status.