Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Systematic Engineering of Intra-Articular Drug Release Profiles Reveals a Key Determinant of Disease-Modifying Efficacy in Post-Traumatic Osteoarthritis.

bioRxiv : the preprint server for biology·2026
Same author

A glycan-based adjuvant expands the breadth and duration of protection of mRNA-based vaccines.

Nature immunology·2026
Same author

A radically simple, ingestible colorimetric biosensor pill for cost-effective, non-invasive monitoring of intestinal inflammation.

Device·2026
Same author

A disease-severity-responsive nanoparticle enables potent ghrelin messenger RNA therapy in osteoarthritis.

Nature nanotechnology·2026
Same author

A Precisely Controlled Long-Acting Immunosuppression Platform Enables Prolonged Survival of Vascularized Composite Allografts.

bioRxiv : the preprint server for biology·2025
Same author

A mechanically resilient soft hydrogel improves drug delivery for treating post-traumatic osteoarthritis in physically active joints.

Proceedings of the National Academy of Sciences of the United States of America·2025

Related Experiment Video

Updated: May 31, 2026

Capturing the Cardiac Injury Response of Targeted Cell Populations via Cleared Heart Three-Dimensional Imaging
08:14

Capturing the Cardiac Injury Response of Targeted Cell Populations via Cleared Heart Three-Dimensional Imaging

Published on: March 17, 2020

Sensing the cardiac environment: exploiting cues for regeneration.

Maria José Nunes Pereira1, Isabel Fidalgo Carvalho, Jeffrey M Karp

  • 1Center of Neurosciences and Cell Biology (CNC), University of Coimbra, 3004-417, Coimbra, Portugal.

Journal of Cardiovascular Translational Research
|July 8, 2011
PubMed
Summary

Biomaterials and stem cells show promise for preserving cardiac tissue post-myocardial infarction through paracrine signaling. Smart materials that sense cardiac cues could enhance long-term heart regeneration.

More Related Videos

A Cardiac Microphysiological System for Studying Ca2+ Propagation via Non-genetic Optical Stimulation
08:29

A Cardiac Microphysiological System for Studying Ca2+ Propagation via Non-genetic Optical Stimulation

Published on: March 21, 2025

Simultaneous Electrical and Mechanical Stimulation to Enhance Cells' Cardiomyogenic Potential
07:41

Simultaneous Electrical and Mechanical Stimulation to Enhance Cells' Cardiomyogenic Potential

Published on: January 18, 2019

Related Experiment Videos

Last Updated: May 31, 2026

Capturing the Cardiac Injury Response of Targeted Cell Populations via Cleared Heart Three-Dimensional Imaging
08:14

Capturing the Cardiac Injury Response of Targeted Cell Populations via Cleared Heart Three-Dimensional Imaging

Published on: March 17, 2020

A Cardiac Microphysiological System for Studying Ca2+ Propagation via Non-genetic Optical Stimulation
08:29

A Cardiac Microphysiological System for Studying Ca2+ Propagation via Non-genetic Optical Stimulation

Published on: March 21, 2025

Simultaneous Electrical and Mechanical Stimulation to Enhance Cells' Cardiomyogenic Potential
07:41

Simultaneous Electrical and Mechanical Stimulation to Enhance Cells' Cardiomyogenic Potential

Published on: January 18, 2019

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Cardiovascular Research

Background:

  • Exogenous stem cells and biomaterials show potential for cardiac tissue preservation after myocardial infarction.
  • Current stem cell therapies rely on paracrine signaling, but limited cell engraftment hinders long-term benefits.
  • Controlled delivery of bioactive factors via biomaterials is a promising strategy to overcome these limitations.

Purpose of the Study:

  • To review how the cardiac environment influences the release of bioactive cues from cells and biomaterials.
  • To explore the impact of controlled delivery systems on cardiac regeneration after myocardial infarction.
  • To highlight the importance of smart materials for advanced cardiac therapies.

Main Methods:

  • Review of pre-clinical and clinical studies on stem cells and biomaterials for myocardial infarction.
  • Analysis of paracrine signaling mechanisms in cardiac tissue repair.
  • Discussion of challenges and advancements in developing controlled drug delivery systems for cardiac regeneration.

Main Results:

  • Short-term benefits of stem cell therapy are linked to paracrine signaling, influenced by cardiac environmental cues.
  • Limited cell survival and engraftment restrict the long-term efficacy of current cell-based therapies.
  • Development of smart materials capable of sensing the cardiac environment and releasing factors on demand is crucial.

Conclusions:

  • The cardiac environment plays a key role in mediating the release of therapeutic cues from cells and biomaterials.
  • Controlled, on-demand delivery systems are essential for maximizing the regenerative potential of cardiac therapies.
  • Smart biomaterials offer a promising avenue for improving long-term outcomes in heart regeneration after myocardial infarction.