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Updated: May 31, 2026
06:23
Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo
Published on: August 4, 2018
[Principles of perioperative coagulation management]
1Institut für Anästhesiologie, Universitätsspital Zürich, Rämistrasse 100, Zürich, Switzerland. michael.ganter@usz.ch
Summary
Understanding the complex coagulation system is crucial for managing bleeding and thrombosis, especially during surgery. Effective treatment relies on identifying coagulation disorders and applying individualized, algorithm-based interventions.
Area of Science:
- Biochemistry and Physiology
- Hemostasis and Thrombosis
- Cellular Signaling Networks
Context:
- The coagulation system is a intricate network regulating bleeding and clot formation.
- Maintaining hemostatic balance is vital, as disruptions lead to clinical conditions like bleeding and thrombosis.
- Perioperative settings present unique challenges for managing coagulation due to physiological stress and interventions.
Purpose:
- To elucidate the complex pathophysiology of the coagulation system.
- To emphasize the importance of understanding coagulation for effective perioperative management.
- To highlight diagnostic and therapeutic strategies for coagulopathic bleeding.
Summary:
- The coagulation system involves intricate protein and cellular interactions with sensitive control pathways, maintaining a balance between procoagulant and anticoagulant activities.
- Imbalances in this delicate system precipitate bleeding or thrombosis, necessitating a thorough understanding of its pathophysiology, particularly in the perioperative period.
- Effective management involves a comprehensive approach including patient history, clinical assessment, laboratory diagnostics, and point-of-care monitoring to guide proactive, individualized treatment algorithms.
Impact:
- Facilitates improved diagnostic accuracy for coagulation disorders.
- Enables proactive and individualized management of bleeding patients.
- Supports the successful control of coagulopathic bleeding through targeted interventions.
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