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Related Concept Videos

Epistasis Analysis01:09

Epistasis Analysis

Although Mendel chose seven unrelated traits in peas to study gene segregation, most traits involve multiple gene interactions that create a spectrum of phenotypes. When the interaction of various genes or alleles at different locations influences a phenotype, this is called epistasis. Epistasis often involves one gene masking or interfering with the expression of another (antagonistic epistasis). Epistasis often occurs when different genes are part of the same biochemical pathway. The...
Gene-Environment Interactions01:20

Gene-Environment Interactions

Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
Epistasis01:39

Epistasis

In addition to multiple alleles at the same locus influencing traits, numerous genes or alleles at different locations may interact and influence phenotypes in a phenomenon called epistasis. For example, rabbit fur can be black or brown depending on whether the animal is homozygous dominant or heterozygous at a TYRP1 locus. However, if the rabbit is also homozygous recessive at a locus on the tyrosinase gene (TYR), it will have an unshaded coat that appears white, regardless of its TYRP1...

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Related Experiment Video

Updated: May 31, 2026

Mapping Bacterial Functional Networks and Pathways in Escherichia Coli using Synthetic Genetic Arrays
14:06

Mapping Bacterial Functional Networks and Pathways in Escherichia Coli using Synthetic Genetic Arrays

Published on: November 12, 2012

Analysis of gene-gene interactions.

Diane Gilbert-Diamond1, Jason H Moore

  • 1Computational Genetics Laboratory, Departments of Genetics and Community and Family Medicine, Dartmouth Medical School, Lebanon, New Hampshire, USA.

Current Protocols in Human Genetics
|July 8, 2011
PubMed
Summary

Gene-gene interactions, or epistasis, complicate the search for disease susceptibility genes. This unit reviews methods for detecting these complex genetic effects in association studies.

Area of Science:

  • Genetics
  • Bioinformatics
  • Statistical Genetics

Background:

  • Gene-gene interactions (epistasis) are increasingly recognized as crucial factors influencing disease risk.
  • Understanding epistasis is essential for accurately identifying disease susceptibility genes.
  • These interactions are likely common due to the complex biological pathways involved in disease.

Purpose of the Study:

  • To introduce the concept of gene-gene interactions (epistasis) as a complicating factor in genetic association studies.
  • To explain the prevalence and significance of epistasis in disease susceptibility.
  • To review statistical and computational methods for detecting and characterizing epistasis.

Main Methods:

  • Focus on genetic association studies for discrete and quantitative traits.

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Analyzing Multifactorial RNA-Seq Experiments with DiCoExpress

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Last Updated: May 31, 2026

Mapping Bacterial Functional Networks and Pathways in Escherichia Coli using Synthetic Genetic Arrays
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Mapping Bacterial Functional Networks and Pathways in Escherichia Coli using Synthetic Genetic Arrays

Published on: November 12, 2012

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
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An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

Published on: November 3, 2010

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Analyzing Multifactorial RNA-Seq Experiments with DiCoExpress

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  • Review of statistical approaches for detecting gene-gene interactions.
  • Overview of computational tools for epistasis analysis.

    • Main Results:

    • Epistasis presents a significant challenge in identifying single disease susceptibility genes.
    • Existing methods are primarily developed for genetic association studies.
    • Characterizing gene-gene interactions requires specialized statistical and computational techniques.

    Conclusions:

    • Gene-gene interactions are a critical consideration in genetic research for complex diseases.
    • Effective detection of epistasis is vital for advancing our understanding of disease etiology.
    • Further development and application of methods for studying epistasis are necessary.