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Related Experiment Video

Updated: May 31, 2026

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections

Published on: August 30, 2014

Sublingual immunotherapy for treating allergic conjunctivitis.

Moises A Calderon¹, Martin Penagos, Aziz Sheikh

¹Department of Allergy and Respiratory Medicine, Royal Brompton Hospital, Imperial College School of Medicine at the National Heart and Lung Institute, London, UK, SW3 6LY.

The Cochrane Database of Systematic Reviews

|July 8, 2011

Summary

This summary is machine-generated.

Sublingual immunotherapy (SLIT) effectively reduces allergic eye symptom scores compared to placebo. While it improves ocular symptoms, its impact on eye drop usage requires further investigation.

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Area of Science:

Ophthalmology
Allergy and Immunology
Clinical Trials

Background:

Allergic ocular symptoms are common comorbidities of allergic rhinitis.
Sublingual immunotherapy (SLIT) is a known treatment for allergic rhinitis, but its efficacy for ocular symptoms is not well-established.

Purpose of the Study:

To evaluate the efficacy of SLIT versus placebo in reducing ocular symptoms.
To assess the impact of SLIT on topical ocular medication requirements and conjunctival immediate allergen sensitivity.

Main Methods:

Systematic review and meta-analysis of 42 randomized controlled trials.
Included double-masked, placebo-controlled trials evaluating SLIT for allergic rhinoconjunctivitis or allergic conjunctivitis.
Primary outcome: total ocular symptom scores; secondary outcomes: individual symptom scores, medication use, and allergen sensitivity.

Main Results:

SLIT significantly reduced total ocular symptom scores (SMD -0.41) and individual symptoms like red, itchy, and watery eyes compared to placebo.
SLIT increased the threshold dose for conjunctival allergen provocation (SMD 0.35).
No significant reduction was observed in the use of ocular eye drops (SMD -0.10).

Conclusions:

SLIT is moderately effective in alleviating ocular symptom scores in allergic rhinoconjunctivitis and allergic conjunctivitis.
Concerns exist regarding the quality of evidence, including allocation concealment, heterogeneity, and potential publication bias.
Further rigorous studies are needed to assess long-term effectiveness and cost-effectiveness.