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Published on: January 25, 2019
[Effects of vitrectomy as a treatment for proliferative diabetic retinopathy in young patients]
Ayumi Usui1, Masatoshi Kiyokawa, Itaru Kimura
1Department of Ophthalmology, Juntendo University Urayasu Hospital, Japan. ayumi820226@hotmail.com
Insights
Vitrectomy improved vision in many young patients with proliferative diabetic retinopathy (PDR). However, neovascular glaucoma (NVG) remained a significant cause of vision loss in this demographic.
Area of Science:
- Ophthalmology
- Diabetology
- Surgical Innovation
Context:
- Proliferative diabetic retinopathy (PDR) poses a significant threat to vision, particularly in younger individuals.
- Vitrectomy is a surgical intervention aimed at managing complications arising from PDR.
- Understanding treatment outcomes in younger PDR patients is crucial for long-term visual health management.
Purpose:
- To evaluate the efficacy and complications of vitrectomy in patients under 40 with PDR.
- To identify risk factors associated with adverse outcomes, specifically neovascular glaucoma (NVG), following vitrectomy for PDR.
Summary:
- Retrospective analysis of 60 eyes from 37 patients under 40 with PDR undergoing primary vitrectomy.
- Visual acuity improved in 72% of cases; however, 22% experienced deterioration.
- Neovascular glaucoma (NVG) was a primary cause of severe visual impairment, with male gender, hypertension, and proteinuria identified as risk factors.
Impact:
- Vitrectomy can restore vision in a majority of young PDR patients.
- Postoperative NVG is a critical complication in this population, necessitating further research into its multifactorial causes.
- Lens preservation during vitrectomy may reduce the risk of NVG, suggesting potential modifications to surgical approaches.
Purpose:
To investigate the effects of vitrectomy as a treatment for the proliferative diabetic retinopathy (PDR) in patients under 40 years old.
Methods:
Sixty eyes of 37 patients under 40 years old with PDR who had undergone vitrectomy for the first time in Juntendo University Urayasu Hospital were included in this study. Preoperative condition, operation methods, visual acuity after operation and complications both during or after operation, especially neovascular glaucoma (NVG), were reviewed retrospectively.
Results:
Visual acuity improved in 43 eyes (72%) by more than 0.2 logMAR compared to that before the operation, remained stable in 4 eyes (6%) and deteriorated in 13 eyes (22%) by more than 0.2 logMAR compared to that before operation. Optic atrophy and phthisis caused by NVG constituted 69% of the causes of complicated final visual acuity. Male patients and patients who had both hypertension and proteinuria had significantly higher prevalence of NVG after vitrectomy (p < 0.05), and patients who retained their lens after the first vitrectomy had a significantly lower prevalence of NVG after the operation (p < 0.05).
Conclusions:
In young PDR patients under 40 years old, postoperative NVG was the main reason for severe visual impairment. Multifactorial causes, both general and ophthalmic seem to be implicated in the onset and progression of NVG derived from PDR.
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