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Published on: September 20, 2019
Practical considerations in cooperative therapeutic trials
Abstract:
Various practical problems associated with cooperative therapeutic trials are discussed from the experience obtained during the U. S. Veterans Administration Cooperative Study on Antihypertensive Agents. The problems discussed include stratification of patients on the basis of severity, methods and precautions for achieving double-blind therapeutic regimens, methods for obtaining uniformity of data in different hospitals, and the need for inserting modifications in the protocol to take care of the patients developing life threatening complications. Other practical problems discussed include the need for obtaining the cooperation of the ward physicians and the problem associated with defaulters and those who do not follow the prescribed regimens. Experimental design helps to restrict errors introduced by variance between hospitals. Cooperative trials have goals and use methods which are somewhat different from the classical methods and aims of laboratory research, and should be evaluated in their proper frame of reference.
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