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Enzyme immobilisation in permselective microcapsules.

Pavadee Pachariyanon¹, Ekkehard Barth, David W Agar

¹Laboratory of Technical Chemistry B, Faculty of Bio- and Chemical Engineering, TU Dortmund, 44227 Dortmund, Germany. Pachariyanon.Pavadee@bci.tu-dortmund.de

Journal of Microencapsulation

|July 9, 2011

Summary

This summary is machine-generated.

Calcium alginate membranes modified with silica additives show improved size-exclusion properties for microcapsule shells. Encapsulated dextranase enzyme retains high activity and stability over multiple reaction cycles.

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Area of Science:

Materials Science
Biotechnology
Chemical Engineering

Background:

Calcium alginate membranes are utilized in microencapsulation.
Silica additives can modify membrane properties.
Efficient enzyme encapsulation is crucial for biocatalysis.

Purpose of the Study:

To investigate the permselective behavior of silica-modified calcium alginate membranes.
To evaluate these membranes as microcapsule shells for enzyme immobilization.
To assess the impact of magnetic nanoparticles on mass transport and enzyme performance.

Main Methods:

Preparation of hollow microcapsules using double concentric nozzles.
Diffusion experiments and High-Performance Liquid Chromatography (HPLC) for membrane characterization.
Enzyme activity and stability assays for encapsulated dextranase.

Main Results:

Modified membranes demonstrated enhanced size-exclusion properties compared to unmodified ones.
Magnetic nanoparticles showed a slight improvement in mass transport within microcapsules.
Encapsulated dextranase retained approximately 80% of free enzyme activity and stability over eight cycles.

Conclusions:

Silica-modified calcium alginate membranes are effective for microencapsulation with improved selectivity.
Enzyme immobilization within these microcapsules maintains high catalytic efficiency and durability.
This approach holds promise for applications in biocatalysis and controlled release systems.