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Anal ulcerations due to cytomegalovirus in patients with AIDS. Report of six cases
T Puy-Montbrun1, R Ganansia, N Lemarchand
1Départment of Coloproctology, Hôpital Léopold Bellan, Paris, France.
Abstract:
Lesions due to cytomegalovirus (CMV) are frequent in the immunocompromised patient. This is particularly the case in patients with AIDS, where the colon and rectum are the regions most often involved. The authors report six cases of anal ulcerations due to CMV in patients with AIDS. These lesions, confirmed histologically, were either isolated or associated with other localizations. Treatment is based on specific antiviral agents but resistance and recurrence can occur. The current report underlines the importance of histologic examination of anal lesions in HIV-infected subjects.
Insights
Cytomegalovirus (CMV) anal ulcerations are common in patients with acquired immunodeficiency syndrome (AIDS). Histologic examination is crucial for diagnosing these lesions, even when other sites are involved, and treatment may face resistance or recurrence.
Area of Science:
- Gastroenterology
- Infectious Diseases
- Virology
Background:
- Cytomegalovirus (CMV) infections frequently affect immunocompromised individuals.
- The colon and rectum are common sites for CMV lesions in patients with acquired immunodeficiency syndrome (AIDS).
Observation:
- Six cases of anal ulcerations caused by CMV in patients with AIDS were documented.
- These anal lesions were histologically confirmed and could be isolated or associated with other CMV localizations.
Findings:
- Histologic examination is essential for identifying CMV anal ulcerations in HIV-infected individuals.
- Treatment with antiviral agents can be complicated by drug resistance and disease recurrence.
Implications:
- Early and accurate diagnosis of CMV anal lesions is critical for appropriate patient management.
- Understanding the potential for resistance and recurrence informs long-term treatment strategies for CMV in AIDS patients.