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Related Experiment Videos

CD30 expression in non-Hodgkin's lymphoma.

M Piris1, D C Brown, K C Gatter

  • 1Nuffield Department of Pathology, John Radcliffe Hospital, Oxford, UK.

Histopathology
|September 1, 1990
PubMed
Summary

CD30 antigen positivity alone is insufficient for diagnosing anaplastic large cell lymphoma (ALCL). Epithelial membrane antigen (EMA) may be more useful for distinguishing between anaplastic and non-anaplastic lymphoma types. Survival rates did not significantly differ between these groups in short-term follow-up.

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Area of Science:

  • Hematopathology
  • Oncology
  • Immunology

Background:

  • The CD30 antigen is considered a hallmark of anaplastic large cell lymphoma (ALCL).
  • CD30 expression is also observed in other high-grade non-Hodgkin's lymphomas (NHLs).
  • Distinguishing ALCL from other CD30+ lymphomas based solely on CD30 expression is challenging.

Purpose of the Study:

  • To evaluate the diagnostic utility of CD30 in identifying ALCL.
  • To compare the immunophenotypic and clinical features of CD30+ lymphomas.
  • To assess the prognostic significance of CD30 expression in high-grade NHLs.

Main Methods:

  • Analysis of approximately 500 lymphomas, identifying 17 cases of ALCL and 36 other CD30+ lymphomas.
  • Immunohistochemical staining using monoclonal antibodies for CD30 (Ki-1, BerH2) and epithelial membrane antigen (EMA).

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  • Review of clinical data and short-term follow-up for patient survival.

    • Main Results:

    • CD30 was strongly expressed in ALCL but also present in 36 other high-grade, non-anaplastic lymphomas.
    • EMA staining appeared more effective than CD30 for differentiating anaplastic from non-anaplastic types.
    • No significant differences in age, sex, clinical presentation, or short-term survival were observed between ALCL, other CD30+ lymphomas, and general high-grade NHLs.

    Conclusions:

    • CD30 positivity alone is not sufficient for diagnosing ALCL.
    • EMA is a potentially more reliable marker for distinguishing ALCL.
    • Current evidence suggests limited justification for differentiating ALCL or CD30+ lymphomas from other high-grade NHLs in general clinical practice, pending larger studies.