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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
The Bone Matrix01:18

The Bone Matrix

Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in acid or...
Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations01:26

Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations

Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
What is the Skeletal System?01:02

What is the Skeletal System?

Overview
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...

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A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
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Published on: June 2, 2022

[Basic calcium phosphate crystal deposition disease].

Thomas Bardin1, Pascal Richette

  • 1Université Paris 7, Assistance-publique-Hôpitaux de Paris, hôpital Lariboisière, fédération de rhumatologie, UFR médicale, 2, rue Ambroise-Paré 75475 Paris cedex 10, France. thomas.bardin@lrb.aphp.fr

Presse Medicale (Paris, France : 1983)
|July 9, 2011
PubMed
Summary
This summary is machine-generated.

Hydroxyapatite crystals commonly cause periarticular disease, especially in the shoulder. Diagnosis involves imaging, and treatment ranges from rest and medication to surgical removal for chronic pain.

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Area of Science:

  • Rheumatology
  • Orthopedics
  • Crystal-induced Arthropathies

Context:

  • Periarticular hydroxyapatite crystal deposition disease is a frequent cause of joint inflammation.
  • While any joint can be affected, the shoulder is the most commonly involved site.

Purpose:

  • To outline the etiology, diagnosis, and management of hydroxyapatite crystal-related periarticular disease.
  • To highlight the clinical presentation and diagnostic modalities for this condition.

Summary:

  • Hydroxyapatite crystals precipitate in periarticular tissues, leading to conditions like tendinitis and bursitis, which can mimic infection.
  • Diagnosis is primarily achieved through imaging techniques such as X-rays and ultrasounds.
  • Acute symptoms are managed with conservative measures including rest, NSAIDs, and corticosteroids, while chronic shoulder pain may necessitate surgical deposit removal.

Impact:

  • Provides a comprehensive overview for clinicians managing patients with suspected hydroxyapatite crystal deposition disease.
  • Emphasizes the importance of accurate diagnosis to differentiate from infectious processes.
  • Informs treatment strategies, from conservative management to surgical intervention for refractory cases.