[Cell cycle and molecular targets: CDK inhibition]
Philippe Carassou1, Laurent Meijer, Sylvestre Le Moulec
1HIA Legouest, service de médecine interne, BP 90001, 57077 Metz Cedex 3, France.
Abstract:
Protein phosphorylation is a fundamental post-translational modification. It regulates a large number of critical cellular processes (differentiation, division, proliferation, apoptosis). Cell division is a process including a series of phases by which a parent cell divides into two daughter cells. The cells enter these stages then progress within the cell division under an accurate control by many proteins. These proteins are activated by phosphorylation. Cyclin-dependent kinases are responsible for this phosphorylation and therefore represent potential therapeutic targets especially in oncology.
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