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Related Experiment Video

Updated: May 31, 2026

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines

Published on: April 21, 2022

Predicting survival in malignant mesothelioma.

A W Musk¹, N Olsen, H Alfonso

¹Schools of Population Health and Medicine and Pharmacology, University of Western Australia , Western Australia, Australia. Bill.Musk@health.wa.gov.au

The European Respiratory Journal

|July 9, 2011

Summary

Malignant mesothelioma (MM) survival has modestly improved over five decades in Western Australia, with earlier diagnosis contributing to gains. However, this fatal disease still shows no complete remissions despite increased medical interventions.

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Area of Science:

Oncology
Epidemiology
Public Health

Background:

Malignant mesothelioma (MM) is a fatal cancer with increasing incidence and healthcare costs.
Understanding survival trends and prognostic factors is crucial for managing this disease.

Purpose of the Study:

To examine changes in survival and identify factors affecting survival for malignant mesothelioma (MM) patients in Western Australia over five decades (up to 2005).

Main Methods:

Retrospective analysis of all diagnosed MM cases in Western Australia via the Mesothelioma Registry.
Cox regression analysis to assess associations between clinical variables (sex, age, diagnosis date/method, site, histology) and survival.
Clinical notes reviewed for symptom onset and performance status in a sample of cases.

Main Results:

Survival is inversely related to age and worse for males and peritoneal MM.
Sarcomatoid histology is associated with a poorer prognosis compared to epithelioid and biphasic subtypes.
Median survival has improved significantly since the 1970s, with incremental gains thereafter, partly due to earlier diagnosis.

Conclusions:

While survival for malignant mesothelioma (MM) has shown modest improvements over 50 years, driven by earlier diagnosis and potentially better management, the disease remains universally fatal.
No complete remissions have been observed, highlighting the need for continued research into more effective treatments.