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Published on: May 10, 2024
Paraoxonase-1 192/55 polymorphisms and the risk of lung cancer in a Turkish population
Pinar Aksoy-Sagirli1, Bedia Cakmakoglu, Turgay Isbir
1Department of Biochemistry, Pharmacy Faculty, Istanbul University, 34116, Istanbul, Turkey. aksoyp@istanbul.edu.tr
Aim:
The purpose of the present study was to investigate the possible association of paraoxonase-1 (PON1) 192/55 polymorphisms with lung cancer (LC) risk in a Turkish population.
Materials And Methods:
A population-based, case-control study was carried out, including 223 patients with LC and 234 controls. The frequencies of PON1 192/55 genotypes were compared in patient and control groups using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis.
Results:
Distribution of PON1 192 R (+) genotype was found to be significantly higher in patients with LC compared to the controls (odds ratio: 1.497, 95% confidence interval: 1.034-2.166). This difference was especially noteworthy in patients with small cell carcinoma and squamous cell carcinoma.
Conclusion:
This is the first case-control study on the association between PON1 polymorphisms and LC susceptibility in a Turkish population. Our results suggest that PON1 192 polymorphsim is associated with an increased risk of LC in the Turkish population and may be a useful genetic marker for small cell and squamous cell carcinoma.
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