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Related Concept Videos

Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
Ischemic Stroke ll: Pathophysiology01:15

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An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

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Related Experiment Video

Updated: May 31, 2026

AAV Systems and Mouse Models for Investigating Ectopic Expression of Neurod1 in Transduced Cells at Subacute and Chronic Times Post-Ischemic Stroke
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AAV Systems and Mouse Models for Investigating Ectopic Expression of Neurod1 in Transduced Cells at Subacute and Chronic Times Post-Ischemic Stroke

Published on: November 29, 2024

Restoring neuronal function after stroke by cell replacement: anatomic and functional considerations.

Marcel Dihné1, Hans-Peter Hartung, Rüdiger J Seitz

  • 1Heinrich-Heine-University, Duesseldorf, Germany. marcel.dihne@uni-duesseldorf.de

Stroke
|July 9, 2011
PubMed
Summary
This summary is machine-generated.

Cell-based stroke therapies show promise for restoring neuronal function. This review identifies potential brain targets and cell types for neuronal substitution, leveraging post-stroke plasticity for brain repair.

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Related Experiment Videos

Last Updated: May 31, 2026

AAV Systems and Mouse Models for Investigating Ectopic Expression of Neurod1 in Transduced Cells at Subacute and Chronic Times Post-Ischemic Stroke
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Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

Published on: May 31, 2017

Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Stroke Research

Background:

  • Restoring neuronal function after stroke remains a significant clinical challenge.
  • Cell-based therapies show potential in animal models but require better understanding of targets and integration.
  • Stroke-induced secondary changes complicate therapeutic strategies for neuronal substitution.

Purpose of the Study:

  • To identify candidate brain structures and cell types for cell-based stroke therapy.
  • To explore strategies for implementing new neuronal functionality in stroke-damaged brains.
  • To integrate cell grafting with concepts of post-stroke neural plasticity.

Main Methods:

  • Review of experimental animal models of cell-based stroke therapy.
  • Analysis of current concepts in post-stroke neural plasticity.
  • Identification of anatomic targets and cell types for neuronal substitution.

Main Results:

  • Candidate brain structures and cell types for neuronal substitution are proposed.
  • Strategies for integrating cell grafts with existing neural networks are discussed.
  • The role of post-stroke plasticity in facilitating functional recovery is highlighted.

Conclusions:

  • Understanding the anatomic targets and cell types is crucial for effective cell-based stroke therapies.
  • Leveraging post-stroke plasticity offers a promising avenue for neuronal substitution.
  • Further research is needed to define optimal strategies for cell-based brain repair after stroke.