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Extranodal NK/T-cell lymphoma, nasal type
Prescilla B Wood1, Sachin R Parikh, John R Krause
1Departments of Pathology (Wood, Krause) and Radiology (Parikh), Baylor University Medical Center at Dallas and Baylor Charles A. Sammons Cancer Center.
Proceedings (Baylor University. Medical Center)
|July 9, 2011
Summary
This case study details extranodal NK/T-cell lymphoma, nasal type, a rare cancer in Western countries, diagnosed in a Southeast Asian man. The patient successfully underwent chemotherapy, radiotherapy, and a stem cell transplant.
Area of Science:
- Oncology
- Hematology
- Immunology
Background:
- Extranodal NK/T-cell lymphoma, nasal type, is a rare malignancy in Western populations.
- This lymphoma subtype is more common in Asian and Native American populations.
- The case highlights a rare presentation in a Southeast Asian individual.
Purpose of the Study:
- To report a rare case of extranodal NK/T-cell lymphoma, nasal type.
- To describe the diagnostic process and co-occurring alpha-E thalassemia.
- To document the treatment course and outcome.
Main Methods:
- Endoscopic sinus surgery for diagnosis.
- Blood and bone marrow examination for staging and co-morbidities.
- Multimodal treatment including chemotherapy, radiotherapy, and stem cell transplantation.
Main Results:
- Confirmation of extranodal NK/T-cell lymphoma, nasal type.
- Diagnosis of alpha-E thalassemia.
- Successful stem cell transplant with 100% engraftment.
Conclusions:
- Extranodal NK/T-cell lymphoma, nasal type, requires a high index of suspicion, especially in endemic populations.
- Multidisciplinary management is crucial for rare lymphomas.
- Stem cell transplantation can be an effective treatment option.
