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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...

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Real Time Detection of In Vitro Tumor Cell Apoptosis Induced by CD8+ T Cells to Study Immune Suppressive Functions of Tumor-infiltrating Myeloid Cells
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Real Time Detection of In Vitro Tumor Cell Apoptosis Induced by CD8+ T Cells to Study Immune Suppressive Functions of Tumor-infiltrating Myeloid Cells

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CD8+ Lymphomatoid Papulosis.

Ji Hyun Sim1, You Chan Kim

  • 1Department of Dermatology, Ajou University School of Medicine, Suwon, Korea.

Annals of Dermatology
|July 9, 2011
PubMed
Summary
This summary is machine-generated.

This report details a rare case of CD8 positive lymphomatoid papulosis (LyP), a condition typically characterized by CD4 expression. The findings contribute to understanding variations in this clinically benign skin disorder.

Keywords:
CD8+Lymphomatoid papulosis

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Area of Science:

  • Dermatopathology
  • Immunohistochemistry
  • Oncology

Background:

  • Lymphomatoid papulosis (LyP) is a rare skin condition with malignant histology but benign clinical behavior.
  • Typical immunophenotyping of LyP lesions shows CD4 positivity and CD8 negativity.
  • CD8 positive LyP is an uncommon variant requiring careful diagnostic consideration.

Observation:

  • A 43-year-old male presented with asymptomatic erythematous papules on his axilla and thigh.
  • Histopathology revealed a wedge-shaped infiltrate with atypical lymphoid cells.
  • Immunophenotyping demonstrated neoplastic cells positive for CD3, CD8, and CD30, and negative for CD4, CD20, and CD56.

Findings:

  • This case represents a rare instance of CD8 positive lymphomatoid papulosis.
  • The immunophenotype contrasts with the more common CD4 positive LyP.
  • The presence of CD8 positivity in LyP expands the known spectrum of this condition.

Implications:

  • Highlights the importance of comprehensive immunophenotyping in diagnosing LyP variants.
  • Contributes to the literature on CD8 positive LyP, aiding future research.
  • May influence diagnostic criteria and understanding of LyP pathogenesis.