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Related Experiment Video

Updated: May 31, 2026

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

Is the GSTM1 null polymorphism a risk factor in primary open angle glaucoma?

Auta Viviane Rocha¹, Teddy Talbot, Thiago Magalhães da Silva

¹Universidade Estadual de Santa Cruz, Departamento de Ciências da Saúde, Laboratório de Farmacogenômica e Epidemiologia Molecular, Ilhéus, Bahia, Brazil.

Molecular Vision

|July 9, 2011

Summary

Glutathione S-transferase (GST) gene variations, particularly the GSTM1 null polymorphism, are linked to an increased risk of primary open angle glaucoma (POAG). These genetic factors also correlate with more severe disease characteristics in the Brazilian population.

Related Experiment Videos

Last Updated: May 31, 2026

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

Area of Science:

Genetics
Ophthalmology
Molecular Biology

Background:

Primary open angle glaucoma (POAG) is a leading cause of irreversible blindness worldwide.
Glutathione S-transferases (GSTs) are crucial enzymes involved in detoxification and cellular protection.
Genetic polymorphisms in GST genes may influence susceptibility to complex diseases like POAG.

Purpose of the Study:

To investigate the association between polymorphisms in glutathione S-transferase (GST) genes (GSTM1, GSTT1, GSTP1) and the risk of primary open angle glaucoma (POAG).
To explore the relationship between these GST gene polymorphisms and the clinical features of POAG.

Main Methods:

A case-control study was conducted with 87 Brazilian POAG patients and 85 healthy controls.
Blood samples were analyzed for polymorphisms in GSTM1, GSTT1, and GSTP1 genes using polymerase chain reaction (PCR) methods.
Genotypes were compared between POAG patients and controls, and associations with clinical parameters were assessed.

Main Results:

The GSTM1 null polymorphism was significantly more prevalent in POAG patients compared to controls (OR: 2.1).
Combined genotypes (GSTM1 null/GSTT1+ and GSTM1 null/GSTP1 Ile/Val or Val/Val) were associated with an increased risk of POAG.
Specific GST genotypes correlated with higher intraocular pressure (IOP) and more severe optic nerve and visual field defects.

Conclusions:

The GSTM1 null polymorphism is a significant risk factor for POAG in the Brazilian population.
GST gene polymorphisms may influence POAG pathogenesis and disease severity.
Further research is warranted to elucidate the role of GSTs in glaucoma development.