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Related Experiment Video

Updated: May 31, 2026

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

Milk alkali and hydrochlorothiazide: a case report.

Babar Parvez¹, Chinenye Emuwa, Marquetta L Faulkner

¹Department of Internal Medicine, Meharry Medical College, 1818 Albion Street, Nashville, TN 37208, USA.

Case Reports in Medicine

|July 9, 2011

Summary

Hypercalcemia, a common clinical issue, can result from excessive calcium intake and alkali use, especially with thiazide diuretics. This case highlights milk-alkali syndrome as a significant cause of high blood calcium levels.

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Last Updated: May 31, 2026

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

Area of Science:

Nephrology
Endocrinology
Internal Medicine

Background:

Hypercalcemia is a frequent clinical condition with hyperparathyroidism and malignancy as primary causes.
Milk-alkali syndrome, linked to calcium and alkali ingestion, is emerging as the third leading cause of hypercalcemia.
Thiazide diuretics are commonly prescribed for hypertension and can exacerbate hypercalcemia.

Observation:

This paper details a case of milk-alkali syndrome.
The patient presented with hypercalcemia due to over-the-counter calcium and alkali consumption for acid reflux.
Concomitant use of a thiazide diuretic for hypertension was noted.

Findings:

Excessive intake of calcium and absorbable alkali can lead to milk-alkali syndrome.
Thiazide diuretics can potentiate hypercalcemia in patients with milk-alkali syndrome.
This combination of factors presents a significant risk for developing severe hypercalcemia.

Implications:

Clinicians should consider milk-alkali syndrome in patients with hypercalcemia, particularly those using calcium supplements and alkali medications.
Awareness of the synergistic effect between calcium/alkali intake and thiazide diuretics is crucial for prevention and management.
This case underscores the importance of a thorough medication and supplement history in diagnosing and treating hypercalcemia.