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The prediabetic period: review of clinical aspects

Sang Youl Rhee1, Jeong-Taek Woo

  • 1Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine; Research Institute of Endocrinology, Kyung Hee University, Seoul, Korea.

Diabetes & Metabolism Journal
|July 9, 2011
PubMed

Insights

Prediabetes (preDM), characterized by hyperglycemia below diabetes mellitus diagnostic criteria, is a growing global concern. This condition significantly elevates risks for diabetes and cardiovascular disease, necessitating a deeper understanding of its clinical significance.

Area of Science:

  • Endocrinology
  • Metabolic Disorders
  • Public Health

Background:

  • Prediabetes (preDM) is defined as hyperglycemia not meeting diabetes mellitus (DM) diagnostic criteria.
  • Global prevalence of preDM is rising, posing significant health challenges.
  • PreDM is a recognized major risk factor for developing DM and cardiovascular diseases.

Purpose of the Study:

  • To review the clinical aspects of prediabetes.
  • To discuss the evolution of prediabetes diagnostic criteria.
  • To examine the epidemiology, pathophysiology, and clinical significance of prediabetes.

Main Methods:

  • Literature review of clinical studies and epidemiological data on prediabetes.
  • Analysis of diagnostic criteria changes over time.
  • Synthesis of information on pathophysiological characteristics and clinical impact.

Main Results:

  • Prediabetes encompasses impaired fasting glucose and impaired glucose tolerance subtypes.
  • Current medical understanding views prediabetes primarily as a risk factor, not an independent disease.
  • The review highlights the increasing prevalence and established risks associated with prediabetes.

Conclusions:

  • Prediabetes represents a critical transitional stage in glucose metabolism.
  • Understanding prediabetes's clinical significance is vital for proactive health management and disease prevention.
  • Further research and clinical attention are warranted for this growing public health issue.

Keywords:
Diabetes mellitus, type 2Insulin resistanceKoreaPrediabetic state

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