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Related Concept Videos

Gas Chromatography: Types of Detectors-I01:21

Gas Chromatography: Types of Detectors-I

There are different types of detectors used in gas chromatography, each with its own specific properties that make it suitable for detecting certain types of analytes. The most commonly used detectors in GC are thermal conductivity detector (TCD), flame ionization detector (FID), and electron capture detector (ECD).
TCD is the earliest and most widely used detector that operates by measuring the changes in the thermal conductivity of the carrier gas. When a sample compound enters the detector,...
Thermosensation01:43

Thermosensation

Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
Gas Chromatography: Types of Detectors-II01:19

Gas Chromatography: Types of Detectors-II

In gas chromatography, different detectors are employed to meet specific analytical needs. These detectors are often categorized based on their detection mechanisms and the types of compounds they are best suited to analyze. Thermal Conductivity Detectors (TCD), Flame Ionization Detectors (FID), and Electron Capture Detectors (ECD) represent common categories, each with unique operating principles and applications. However, beyond these, several other detectors are designed for more specialized...
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Glass-bulb Thermometer:
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Absorption of Radiation

The rate of heat transfer by emitted radiation is described by the Stefan-Boltzmann law of radiation:

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Thermal Measurement Techniques in Analytical Microfluidic Devices
08:29

Thermal Measurement Techniques in Analytical Microfluidic Devices

Published on: June 3, 2015

Thermal lens detection device.

Kazuma Mawatari1, Toshinori Ohashi, Tomohiko Ebata

  • 1Department of Applied Chemistry, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656, Japan.

Lab on a Chip
|July 9, 2011
PubMed
Summary
This summary is machine-generated.

A new portable thermal lens detection device offers easy, sensitive detection of nonfluorescent molecules. This innovation simplifies complex optical alignments, enabling practical applications in microsystems.

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Area of Science:

  • Analytical Chemistry
  • Optical Sensing
  • Microfluidics

Background:

  • Traditional thermal lens detection systems require laborious optical alignment.
  • There is a need for portable, user-friendly detectors for nonfluorescent molecules.
  • Integrating sensitive detection methods into microfluidic systems is challenging.

Purpose of the Study:

  • To develop an easy-to-use, portable, and sensitive thermal lens detection device.
  • To simplify the optical alignment process for thermal lens detection.
  • To enable the integration of thermal lens detection into microsystems for enhanced sensitivity.

Main Methods:

  • Coaxial laser diodes (658 nm excitation, 785 nm probe) coupled to a single-mode optical fiber.
  • Microfluidic chip with an integrated optical fiber holder and micro-lenses (NA 0.2).
  • Design of micro-lenses with specific chromatic aberration (50 μm) for sensitive detection.

Main Results:

  • Achieved a lower limit of detection of 10 nM for nickel(II) phthalocyaninetetrasulfonic acid tetrasodium salt.
  • Detected as few as 200 zmol of molecules with an absorbance of 9 × 10(-6) AU.
  • Demonstrated high reproducibility with a coefficient of variance of 3.6% for repeated optical probe attachment-detachment.

Conclusions:

  • The developed device simplifies thermal lens detection, requiring only fiber attachment-detachment.
  • The portable and sensitive detector is suitable for practical applications and integration into microsystems.
  • Achieved sensitivities several orders of magnitude higher than conventional absorptiometry in realized microsystems.