Related Experiment Video
Updated: May 31, 2026
11:14
Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture
Published on: October 12, 2018
Granuloma inguinale (Donovanosis).
Sarita Maria de Fátima Martins de Carvalho Bezerra1, Marcio Martins Lobo Jardim, Valdir Bandeira da Silva
1STD outpatient clinic, Clinics Hospital, Federal University of Pernambuco (PE), Brazil. saritamartins@uol.com.br
Anais Brasileiros De Dermatologia
|July 9, 2011
Summary
This study visually documents granuloma inguinale, also known as donovanosis, a sexually transmitted infection. It highlights common clinical presentations and microscopic findings of Donovan bodies in affected cells.
Area of Science:
- Dermatology
- Infectious Diseases
- Microbiology
Background:
- Granuloma inguinale (donovanosis) is a chronic bacterial sexually transmitted infection.
- It is endemic in tropical and subtropical regions globally.
- Clinical manifestations vary, requiring accurate diagnosis.
Purpose of the Study:
- To illustrate the common clinical forms of granuloma inguinale in both males and females.
- To present microscopic diagnostic features of donovanosis.
Main Methods:
- Visual documentation of clinical presentations.
- Microscopic examination of direct smears using Giemsa stain.
- Histological analysis to identify Donovan bodies.
Main Results:
- Images depict two frequent clinical forms of granuloma inguinale.
- Microscopic examination reveals Donovan bodies within mononuclear cells on direct smears.
- Histology shows characteristic rod-shaped Donovan bodies within mononuclear histiocytes.
Conclusions:
- Visual aids are crucial for recognizing common clinical presentations of donovanosis.
- Microscopic identification of Donovan bodies is key for diagnosis.
- Understanding these features aids in managing this endemic STI.
Related Concept Videos
01:12Giardiasis
Giardiasis is a globally prevalent intestinal infection caused by the protozoan parasite Giardia duodenalis (also known as G. lamblia or G. intestinalis). This flagellated protozoan is the most frequently identified intestinal parasite in the United States and worldwide. Transmission primarily occurs via the fecal-oral route, with infection arising from ingestion of water or food contaminated with cysts. Individuals in low-resource settings, international travelers, outdoor enthusiasts, daycare...
01:26Sexually Transmitted Infections
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
01:18Trichomoniasis
Trichomonas vaginalis is a flagellated protozoan parasite and the causative agent of trichomoniasis, one of the most prevalent non-viral sexually transmitted infections in the United States. This extracellular parasite primarily colonizes the lower genitourinary tract in women—particularly the vagina—and in men, the urethra and prostate. Its structural and functional adaptations enable its survival, motility, and pathogenicity within the host environment.Structural Features and Host EntryT.
01:28Amebiasis
Entamoeba histolytica, a protozoan parasite, is responsible for intestinal and extraintestinal amebiasis. Though a significant proportion of infections remain asymptomatic, approximately 50 million individuals annually are estimated to present with clinical disease, resulting in up to 100,000 deaths globally. The disease burden is disproportionately high in regions with lower socioeconomic status, such as parts of India, Africa, Mexico, and Latin America.Etiology and TransmissionThe infective...
01:30Leishmaniasis
Leishmaniasis is a protozoal disease caused by species of the genus Leishmania and transmitted through the bite of infected female sandflies. The parasite exists in two principal morphological forms during its life cycle. A sandfly acquires intracellular amastigotes from an infected reservoir host, such as a dog. Within the sandfly, these forms differentiate into motile, flagellated promastigotes. During a subsequent blood meal, promastigotes are injected into the human host, where they...
01:25Immunodeficiency Diseases
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
There are three main causes of immunodeficiency disorders...