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Mucosa-associated lymphoid tissue in individuals with AIDS
Janainna Grazielle Pacheco Olegario1, Renata Calciolari Rossi e Silva, Vicente de Paula Antunes Teixeira
1Triangulo Mineiro Federal University, Uberaba, MG.
Unlabelled:
Vestibular folds (VF) protect upper airways, but contain fewer immune cells in AIDS patients, which affects the structure of lymphoid follicles (LF).
Objective:
To characterize fibrosis and immunoglobulin production in vestibular fold lymphoid tissues of AIDS patients with or with no infection and malnutrition.
Materials And Methods:
A retrospective study of 71 adult vestibular fold autopsy specimens. The morphological analysis was done using the picrosirius staining method. Immunohistochemical methods consisted of anti-IgA, anti IgG, and anti IgM antibodies.
Results:
Fibrosis was less intense in AIDS patients compared to subjects without AIDS; the same applied to patients with infection or malnutrition. IgA and IgG titers were higher in AIDS patients; IgM titers were higher in cases with infection.
Conclusion:
This study helps understand variations in lymphoid follicle components of AIDS patients; it also shows the influence of architectural changes and the effect of associated respiratory infection and malnutrition on lymphoid follicle function.
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