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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Related Experiment Video

Updated: May 31, 2026

Cell-based Assay to Study Antibody-mediated Tau Clearance by Microglia
07:18

Cell-based Assay to Study Antibody-mediated Tau Clearance by Microglia

Published on: November 9, 2018

Immunotherapy for tauopathies.

Jiaping Gu1, Einar M Sigurdsson

  • 1Department of Physiology and Neuroscience, New York University, School of Medicine, 550 First Avenue, New York, NY 10016, USA.

Journal of Molecular Neuroscience : MN
|July 9, 2011
PubMed
Summary

Targeting pathological tau protein aggregates through active and passive immunization shows promise for Alzheimer's disease and tauopathies. This approach reduces tau pathology in vivo and improves behavioral outcomes in mouse models.

Area of Science:

  • Neuroscience
  • Pathology
  • Immunology

Background:

  • Pathological tau protein aggregates are a hallmark of Alzheimer's disease and tauopathies.
  • Hyperphosphorylation and mutation of tau lead to aggregation and neurotoxicity, correlating with cognitive decline.

Purpose of the Study:

  • To summarize recent advances in targeting tau pathology for therapeutic benefit.
  • To highlight the potential of immunotherapy for Alzheimer's disease and related tauopathies.

Main Methods:

  • Review of active and passive immunization strategies targeting disease-related tau epitopes.
  • Analysis of in vivo studies in mouse models of tauopathy.

Main Results:

  • Immunization successfully reduces pathological tau aggregates in vivo.

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Published on: November 9, 2018

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein
09:22

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein

Published on: January 2, 2015

  • Therapeutic strategies slow or prevent behavioral impairments in mouse models.

    • Conclusions:

    • Targeting tau pathology via immunization is a promising therapeutic strategy.
    • Further research in this field holds potential for treating neurodegenerative diseases.