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Spontaneous Murine Model of Anaplastic Thyroid Cancer

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

Molecular analysis of thyroid tumors.

Feriyl Bhaijee¹, Yuri E Nikiforov

¹Department of Pathology, University of Mississippi Medical Center, Jackson, MS, USA.

Endocrine Pathology

|July 9, 2011

Summary

Thyroid cancer, the most common endocrine malignancy, is increasingly diagnosed. Key genetic alterations like BRAF mutations and RET/PTC rearrangements are vital molecular markers for diagnosis and prognosis.

Area of Science:

Endocrinology
Oncology
Molecular Biology

Background:

Thyroid cancer is the most common endocrine malignancy with rising incidence globally.
Papillary and follicular thyroid carcinomas are the predominant subtypes.
Over 70% of these cancers harbor specific genetic alterations.

Purpose of the Study:

To provide an overview of common genetic alterations in papillary and follicular thyroid carcinoma.
To discuss the diagnostic and prognostic significance of these molecular markers.
To highlight the potential of emerging markers in thyroid nodule diagnosis and patient management.

Main Methods:

Review of common genetic alterations in papillary and follicular thyroid carcinoma.
Analysis of diagnostic and prognostic significance of molecular markers.

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An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

Published on: April 17, 2013

Discussion of emerging molecular markers for improved patient care.

Main Results:

BRAF and RAS point mutations are frequent genetic alterations.
RET/PTC and PAX8/PPARγ rearrangements are also common.
These genetic alterations serve as significant diagnostic and prognostic markers.

Conclusions:

Common genetic alterations are prevalent in papillary and follicular thyroid carcinomas.
These molecular markers are crucial for diagnosis and prognosis.
Emerging markers promise enhanced diagnosis and personalized management of thyroid cancer.