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Updated: May 31, 2026
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Measurement of BK-polyomavirus Non-Coding Control Region Driven Transcriptional Activity Via Flow Cytometry
Published on: July 13, 2019
[BK virus nephropathy after kidney transplantation]
V Bröcker1, A Schwarz, J U Becker
1Institut für Pathologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland. broecker.verena@mh-hannover.de
Der Pathologe
|July 9, 2011
Summary
BK virus causes polyomavirus nephropathy (BKVN) in kidney transplant recipients, leading to potential graft failure. Early screening and immunosuppression reduction are crucial for managing BKVN and improving transplant survival.
Area of Science:
- Virology
- Nephrology
- Immunology
Context:
- BK virus (BKV) and JC virus are human polyomaviruses.
- BKV is the primary cause of polyomavirus nephropathy (BKVN) in kidney transplant patients.
- Asymptomatic BKV infection is common in childhood, persisting in the urinary tract and kidneys.
Purpose:
- To highlight the pathogenic role of BK virus in kidney transplantation.
- To emphasize the diagnostic challenges and clinical significance of BKVN.
- To underscore the importance of early detection and management strategies for BKVN.
Summary:
- BK virus causes BKVN in up to 10% of kidney transplants, with a >50% risk of graft failure.
- BKVN presents as tubulointerstitial nephritis, mimicking acute cellular rejection.
- Hallmarks include cytopathic effects, tubular basement membrane denudation, and nuclear inclusions.
Impact:
- Early diagnosis via blood and urine screening is vital for transplant survival.
- Reduced immunosuppression is a key treatment to clear the virus.
- Effective management of BKVN improves long-term outcomes for renal transplant recipients.
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