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Updated: May 31, 2026
06:15
Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
[Intraocular manifestations of systemic neoplasms]
N E Bechrakis1, G Haas, G Blatsios
1Department of Ophthalmology, Innsbruck Medical University, Innsbruck, Austria. nikolaos.bechrakis@i-med.ac.at
Klinische Monatsblatter Fur Augenheilkunde
|July 9, 2011
Summary
Ocular manifestations like metastases and paraneoplastic syndromes can signal systemic neoplasms. Early fundus examination aids in diagnosing cancers such as von Hippel Lindau syndrome and bowel cancer.
Area of Science:
- Ophthalmology
- Oncology
- Genetics
Context:
- Systemic neoplasms can present with diverse intraocular manifestations.
- These include direct metastases (uveal, retinal, vitreous) from various cancers.
- Genetic syndromes like von Hippel Lindau and familial adenomatous polyposis coli (FAP) have characteristic fundus findings.
Purpose:
- To highlight the spectrum of ocular manifestations associated with systemic malignancies.
- To emphasize the diagnostic and early detection role of fundus examination in specific genetic syndromes.
- To discuss rare paraneoplastic syndromes as potential primary indicators of underlying cancer.
Summary:
- Intraocular involvement in systemic neoplasms encompasses metastases from carcinomas, melanomas, and lymphomas.
- Fundus examination is crucial for diagnosing genetic syndromes (e.g., von Hippel Lindau, FAP) and associated systemic cancers.
- Rare paraneoplastic syndromes (CAR/MAR, PON, BDUMP) can be the initial sign of malignancy.
Impact:
- Enhances understanding of the ophthalmological signs of systemic cancers.
- Promotes early diagnosis of systemic neoplasms through ocular screening.
- Improves patient outcomes by facilitating timely oncological intervention.
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