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Updated: May 31, 2026

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography
Published on: August 11, 2016
Prenatal MR diffusion tractography in a fetus with complete corpus callosum agenesis
1Division of Pediatric Radiology, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital, Baltimore, MD 21287-0842, USA.
Abstract:
Diffusion tensor imaging (DTI) in combination with 3D-tractography reconstructions allows studying the neuro-architecture of complex brain malformations in vivo. Prenatal, in utero DTI has been limited by long acquisition times, poor signal to noise ratio and multiple artifacts. Recent developments in hard- and software allow collection of high quality DTI data sets in utero. We report on the DTI and tractography data of a fetus with a corpus callosum agenesis. Our case shows that nowadays the neuro-architecture of the fetal brain can be studied in excellent detail. Prenatal DTI and tractography may help to improve our understanding of complex brain malformations.
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