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Updated: Aug 9, 2026

Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation
Published on: June 26, 2013
Interleukin-2 suppresses established long-term potentiation and inhibits its induction in the rat hippocampus
V Tancredi1, C Zona, F Velotti
1Dipartimento Medicina Sperimentale e Scienze Biochimiche, Università di Roma Tor Vergata, Italy.
Abstract:
The effects of recombinant interleukin-2 (rIL-2) on the potentiation of the synaptic transmission were studied in rat hippocampal slices by using extracellular field potential recordings. The application of rIL-2 inhibited the induction of both short-term (STP) and long-term potentiation (LTP) in a dose-dependent manner. In addition, rIL-2 (1000 U/ml) reduced both post-tetanic potentiation (PTP) and LTP maintenance phase. The possible involvement of rIL-2 action on the synaptic potentiation with the enzymatic activity of protein kinase systems is discussed.
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