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Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

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Related Experiment Video

Updated: May 31, 2026

A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells
11:15

A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells

Published on: May 6, 2018

Mesenchymal stem cells engineered for cancer therapy.

Khalid Shah1

  • 1Massachusetts General Hospital, Harvard Medical School, Boston, USA. kshah@helix.mgh.harvard.edu

Advanced Drug Delivery Reviews
|July 12, 2011
PubMed
Summary

Mesenchymal stem cells (MSC) show promise as targeted cancer therapies. Engineered MSC can deliver anti-cancer agents, offering new treatment strategies for various cancers.

Area of Science:

  • Oncology
  • Regenerative Medicine
  • Biotechnology

Background:

  • Stem cell-based therapies show promise for treating human diseases.
  • Mesenchymal stem cells (MSC) are emerging as potent anti-cancer agents.
  • MSC possess inherent tumor-homing capabilities, ideal for targeted drug delivery.

Purpose of the Study:

  • To review the current status of Mesenchymal stem cell (MSC)-based cancer therapies.
  • To explore the potential for clinical translation of MSC-based cancer treatments.

Main Methods:

  • Review of pre-clinical and clinical studies on MSC in cancer therapy.
  • Analysis of MSC engineering for targeted anti-cancer agent delivery.
  • Evaluation of methods for in vivo monitoring of MSC migration.

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Mesenchymal Stem Cell Isolation from Pulp Tissue and Co-Culture with Cancer Cells to Study Their Interactions
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Mesenchymal Stem Cell Isolation from Pulp Tissue and Co-Culture with Cancer Cells to Study Their Interactions

Published on: January 7, 2019

Image-Guided Resection of Glioblastoma and Intracranial Implantation of Therapeutic Stem Cell-seeded Scaffolds
09:18

Image-Guided Resection of Glioblastoma and Intracranial Implantation of Therapeutic Stem Cell-seeded Scaffolds

Published on: July 16, 2018

Related Experiment Videos

Last Updated: May 31, 2026

A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells
11:15

A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells

Published on: May 6, 2018

Mesenchymal Stem Cell Isolation from Pulp Tissue and Co-Culture with Cancer Cells to Study Their Interactions
09:30

Mesenchymal Stem Cell Isolation from Pulp Tissue and Co-Culture with Cancer Cells to Study Their Interactions

Published on: January 7, 2019

Image-Guided Resection of Glioblastoma and Intracranial Implantation of Therapeutic Stem Cell-seeded Scaffolds
09:18

Image-Guided Resection of Glioblastoma and Intracranial Implantation of Therapeutic Stem Cell-seeded Scaffolds

Published on: July 16, 2018

Main Results:

  • MSC can be engineered to express anti-proliferative, pro-apoptotic, and anti-angiogenic agents.
  • MSC-based strategies have demonstrated feasibility and efficacy in various cancer models.
  • Real-time monitoring techniques for MSC migration are being established.

Conclusions:

  • Mesenchymal stem cells (MSC) offer a promising platform for targeted cancer therapy.
  • Further research and clinical validation are needed for widespread adoption of MSC-based cancer treatments.