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Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Epilepsy ll: Types01:22

Epilepsy ll: Types

Recurrent seizures, stemming from abnormal electrical activity in the brain, are the defining characteristic of epilepsy, a chronic neurological condition. Because seizure features vary greatly, epilepsy is classified using two systems: by seizure type and by epilepsy syndromes. These classifications enable clinicians to describe seizure patterns and select suitable treatment strategies.I. Classification by Seizure Type1. Focal EpilepsyFocal epilepsy begins in one hemisphere of the brain.
Seizures: Classification01:13

Seizures: Classification

Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Seizures l: Introduction01:20

Seizures l: Introduction

Understanding seizures and epilepsy relies on key definitions that help in recognizing, classifying, and managing these disorders. These definitions provide a framework for recognizing, classifying, and managing seizure disorders.DefinitionsA seizure is a sudden, abnormal burst of electrical activity in the brain that can cause changes in awareness, movement, sensation, or behavior, depending on the area involved. Epilepsy is a chronic condition characterized by recurrent, unprovoked seizures,...

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Related Experiment Video

Updated: May 31, 2026

Frontal Disconnection for Treating Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia in Epilepsy (MOGHE) in the Frontal Lobe
06:04

Frontal Disconnection for Treating Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia in Epilepsy (MOGHE) in the Frontal Lobe

Published on: August 16, 2024

Epilepsy surgery in children with developmental tumours.

Marta García-Fernández1, Concepción Fournier-Del Castillo, Arturo Ugalde-Canitrot

  • 1Epilepsy Monitoring Unit, Neurophysiology Section, Hospital Infantil Universitario Niño Jesús, Madrid, Spain. martagf@hotmail.com

Seizure
|July 12, 2011
PubMed
Summary

Early surgical intervention for developmental brain tumors in children significantly improves seizure control and cognitive outcomes. Prompt treatment is key for optimal long-term results in pediatric epilepsy.

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Last Updated: May 31, 2026

Frontal Disconnection for Treating Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia in Epilepsy (MOGHE) in the Frontal Lobe
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Published on: August 15, 2025

Area of Science:

  • Pediatric Neurology
  • Neurosurgery
  • Developmental Neurobiology

Background:

  • Developmental tumors like dysembryoplastic neuroepithelial tumors (DNET), gangliogliomas (GG), and gangliocytomas (GC) are associated with epilepsy in children.
  • Focal epilepsy often correlates with the location of these brain lesions.

Purpose of the Study:

  • To evaluate the surgical treatment and outcomes for children with histopathologically confirmed developmental tumors and related epilepsy.
  • To analyze pre- and post-operative video-EEG, MRI, and neuropsychological data.
  • To determine the optimal timing for surgical intervention to maximize cognitive outcomes.

Main Methods:

  • Retrospective analysis of 21 children with confirmed developmental tumors and epilepsy.
  • Pre- and post-operative assessment including video-EEG, MRI, and neuropsychological testing.
  • Surgical treatment and follow-up data collection.

Main Results:

  • 95.2% of patients achieved seizure freedom at a mean follow-up of 4.68 years.
  • No significant neuropsychological declines were observed post-surgery.
  • One DNET showed residual tumor growth; one ganglioglioma recurred with anaplastic transformation.

Conclusions:

  • Surgery for pediatric developmental brain tumors and associated epilepsy should be considered before refractory epilepsy criteria are met.
  • Early surgical intervention, especially with early seizure onset, is crucial for optimizing cognitive outcomes.
  • Surgical management offers high rates of seizure control and preserves neuropsychological function.