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Clonorchis sinensis and clonorchiasis, an update
1Department of Parasitology and Tropical Medicine, Institute of Endemic Diseases, Seoul National University College of Medicine, Seoul 110-799, Republic of Korea. hst@snu.ac.kr
Parasitology International
|July 12, 2011
Summary
Clonorchis sinensis, a liver fluke, causes cancer and infects millions globally. Diagnosis and treatment strategies, including chemotherapy, are crucial for controlling this Group 1 carcinogen.
Area of Science:
- * Parasitology and Public Health
- * Molecular Biology and Carcinogenesis
Background:
- * Clonorchis sinensis is a prevalent human liver fluke in East Asia, recognized as a Group 1 biological carcinogen.
- * Over 200 million people are at risk, with 15-20 million infected, leading to significant morbidity.
Purpose of the Study:
- * To review current knowledge on Clonorchis sinensis, focusing on its oncogenesis, diagnostic methods, and therapeutic interventions.
- * To highlight advancements in molecular and omics-based research for understanding fluke-associated carcinogenesis.
Main Methods:
- * Review of existing literature on Clonorchis sinensis epidemiology, pathogenesis, diagnosis, and treatment.
- * Analysis of molecular, omics, diagnostic (ELISA, PCR, real-time PCR, LAMP, imaging), and chemotherapeutic findings.
Main Results:
- * Established link between Clonorchis sinensis infection and human carcinogenesis.
- * Development of sensitive and specific diagnostic tools, including molecular and imaging techniques.
- * Praziquantel remains the primary treatment, with tribendimidine emerging as a promising alternative.
Conclusions:
- * Effective diagnostic and therapeutic strategies are available for clonorchiasis.
- * Integrated control programs involving mass chemotherapy and public education are essential for reducing disease burden and preventing re-infection.
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