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Related Experiment Video

Updated: May 31, 2026

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

Basic research in kidney cancer.

Egbert Oosterwijk¹, W Kimryn Rathmell, Kerstin Junker

¹Department of Urology, University Medical Centre Nijmegen, Nijmegen, The Netherlands. e.oosterwijk@uro.umcn.nl

European Urology

|July 12, 2011

Summary

This summary is machine-generated.

Recent advances in renal cancer research reveal its molecular basis, leading to targeted therapies. Future integration of high-throughput platforms promises personalized treatment for renal cell carcinoma (RCC) patients.

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Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy

Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy

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Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy

Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy

Published on: April 29, 2014

Area of Science:

Oncology
Molecular Biology
Genetics

Background:

Basic research advances enhance prognosis, diagnosis, and treatment for renal cancer patients.
Understanding the molecular underpinnings of renal cancer is crucial for improving patient outcomes.

Purpose of the Study:

To review recent advances in the molecular basis of renal cancer.
To discuss targeted therapies, immunotherapy, and genetic factors in renal cell carcinoma (RCC).
To explore the role of immunity and genetic factors in renal cell carcinoma.

Main Methods:

Review of basic science papers published between 2005 and 2011.
Analysis of data on molecular mechanisms, targeted therapies, and genetic factors in renal cancer.

Main Results:

Renal cancers can be classified by genetic profiles, with aberrant chromatin remodeling a key driver in clear cell RCC.
While numerous biomarkers have emerged, clinical application remains a challenge.
Tyrosine kinase inhibitors (TKIs) are now used, but immunotherapy shows promise, potentially in combination with TKIs.

Conclusions:

Significant progress in understanding RCC molecular mechanisms has yielded targeted therapies.
Ongoing large-scale sequencing efforts identify new therapeutic targets.
Integration of high-throughput platforms is expected to enable personalized cancer treatment for RCC patients.