Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cardiac Catheterization I: Pre-Procedure Overview

Cardiac Catheterization I: Pre-Procedure Overview

Cardiac catheterization is an invasive diagnostic technique used to identify and evaluate structural and functional diseases of the heart and major blood vessels. This technique diagnoses congenital heart disease, coronary artery disease, valvular heart disease, and coronary spasms and assesses ventricular function. It helps guide treatment decisions, including the need for revascularization procedures like percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) and...

Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...

Nephrons

Nephrons

The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma happens...

Acute Kidney Injury II: Pathophysiology

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Pedal Venous Maturation on Duplex Ultrasound Predicts Outcomes after Venous Arterialisation in No Option Chronic Limb Threatening Ischaemia.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2026

Same author

Comparison of outcomes of percutaneous deep venous arterialization in multiple practice settings.

Journal of vascular surgery·2024

Same author

PACE: randomized, controlled, multicentre, multinational, phase III study of PLX-PAD for critical limb ischaemia in patients unsuitable for revascularization: randomized clinical trial.

The British journal of surgery·2024

Same author

Percutaneous Deep Venous Arterialization in Patients with No-Option Critical Limb Ischemia Performed in an Office-Based Laboratory Setting.

Journal of vascular and interventional radiology : JVIR·2023

Same author

Randomized controlled trial of mechanical thrombectomy vs catheter-directed thrombolysis for acute hemodynamically stable pulmonary embolism: Rationale and design of the PEERLESS study.

American heart journal·2023

Same author

Wire Access Preservation Facilitates the Management of External Iliac Artery Compression following Iliac Venous Stent Placement after High-Dose Pelvic Radiation Therapy.

Journal of vascular and interventional radiology : JVIR·2023

Search research articles

Related Experiment Video

Updated: May 31, 2026

Isolation of Glomeruli and In Vivo Labeling of Glomerular Cell Surface Proteins

Isolation of Glomeruli and In Vivo Labeling of Glomerular Cell Surface Proteins

Published on: January 18, 2019

Contrast-induced nephropathy.

John H Rundback¹, Daniel Nahl, Vanessa Yoo

¹Interventional Institute, Holy Name Medical Center, Teaneck, NJ, USA. jrundback@airsllp.com

Journal of Vascular Surgery

|July 12, 2011

Summary

This summary is machine-generated.

Contrast-induced nephropathy (CIN) risk is a growing concern with increased imaging studies. Volume supplementation before contrast administration is currently the most supported strategy for preventing CIN.

More Related Videos

Mouse Model of Acute to Chronic Kidney Disease Transition Induced by Renal Ischemia/Reperfusion Injury

Mouse Model of Acute to Chronic Kidney Disease Transition Induced by Renal Ischemia/Reperfusion Injury

Published on: February 10, 2026

Related Experiment Videos

Last Updated: May 31, 2026

Isolation of Glomeruli and In Vivo Labeling of Glomerular Cell Surface Proteins

Isolation of Glomeruli and In Vivo Labeling of Glomerular Cell Surface Proteins

Published on: January 18, 2019

Mouse Model of Acute to Chronic Kidney Disease Transition Induced by Renal Ischemia/Reperfusion Injury

Mouse Model of Acute to Chronic Kidney Disease Transition Induced by Renal Ischemia/Reperfusion Injury

Published on: February 10, 2026

Area of Science:

Nephrology
Radiology
Cardiology

Background:

Contrast-induced nephropathy (CIN) is a significant adverse event associated with iodinated contrast media.
Increased utilization of contrast-enhanced imaging studies has heightened the need for CIN research.
Varied definitions and diagnostic markers contribute to inconsistent reported CIN incidence.

Purpose of the Study:

To review current understanding of CIN pathogenesis and prevention strategies.
To assess the evidence supporting various methods for reducing CIN risk.
To identify areas requiring further research, particularly randomized trials.

Main Methods:

Literature review of studies on contrast-induced nephropathy.
Analysis of risk assessment and risk reduction strategies.
Evaluation of evidence for preventative measures like volume supplementation, low osmolar contrast media, N-acetylcysteine, and fenoldopam therapy.

Main Results:

Volume supplementation prior to contrast administration is supported by current evidence to reduce CIN hazard.
Other strategies such as low osmolar contrast media, N-acetylcysteine, and fenoldopam therapy show variable levels of evidence.
Further randomized trials are needed to clarify the efficacy of these alternative strategies.

Conclusions:

Volume supplementation is the primary evidence-based strategy for CIN prevention.
The efficacy of other CIN prevention methods requires further investigation through robust clinical trials.
Standardized definitions and markers are needed for consistent CIN incidence reporting.