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Related Concept Videos

DNA Damage can Stall the Cell Cycle02:36

DNA Damage can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
DNA Damage Can Stall the Cell Cycle02:36

DNA Damage Can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
Overview of DNA Repair02:25

Overview of DNA Repair

In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
Chemically...
Overview of DNA Repair02:25

Overview of DNA Repair

In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
Chemically...
Nucleotide Excision Repair01:38

Nucleotide Excision Repair

DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
Nucleotide Excision Repair01:08

Nucleotide Excision Repair

Overview

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Related Experiment Video

Updated: May 31, 2026

Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage
10:59

Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage

Published on: August 21, 2021

miRNA response to DNA damage.

Guohui Wan1, Rohit Mathur, Xiaoxiao Hu

  • 1Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Trends in Biochemical Sciences
|July 12, 2011
PubMed
Summary
This summary is machine-generated.

MicroRNAs (miRNAs) are vital regulators of the DNA damage response (DDR) in eukaryotic cells. This review explores how miRNAs interact with DDR pathways and how their expression changes following DNA damage to maintain genomic integrity.

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Last Updated: May 31, 2026

Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage
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Published on: August 21, 2021

Visualization of DNA Repair Proteins Interaction by Immunofluorescence
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Laser Microirradiation to Study In Vivo Cellular Responses to Simple and Complex DNA Damage
10:44

Laser Microirradiation to Study In Vivo Cellular Responses to Simple and Complex DNA Damage

Published on: January 31, 2018

Area of Science:

  • Molecular Biology
  • Genetics
  • Cell Biology

Background:

  • Genomic integrity is essential for eukaryotic cell function.
  • DNA damage response (DDR) pathways are critical for sensing and repairing DNA damage.
  • MicroRNAs (miRNAs) are emerging as key regulators in cellular processes.

Purpose of the Study:

  • To review recent findings on the role of miRNAs in the DNA damage response.
  • To elucidate the mechanisms by which miRNAs interact with canonical DDR pathways.
  • To discuss the regulation of miRNA expression subsequent to DNA damage.

Main Methods:

  • Literature review of recent scientific publications.
  • Analysis of experimental data on miRNA-DDR interactions.
  • Synthesis of current knowledge on miRNA regulation in response to DNA damage.

Main Results:

  • miRNAs are involved in regulating multiple components of the DDR.
  • miRNA expression levels are altered following DNA damage.
  • Specific miRNAs can either promote or inhibit DDR pathways.

Conclusions:

  • miRNAs are integral components of the DNA damage response network.
  • Understanding miRNA involvement in DDR is crucial for comprehending genomic stability maintenance.
  • Targeting miRNAs may offer novel therapeutic strategies for diseases involving DNA damage.