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Updated: Apr 29, 2026

Olfactory Assays for Mouse Models of Neurodegenerative Disease
Published on: August 25, 2014
Olfactory memory is impaired in a triple transgenic model of Alzheimer disease
Tommaso Cassano1, Adele Romano, Teresa Macheda
1Department of Biomedical Sciences, University of Foggia, Foggia, 71100, Italy. tommaso.cassano@gmail.com
Abstract:
Olfactory memory dysfunctions were investigated in the triple-transgenic murine model of Alzheimer's disease (3 × Tg-AD). In the social transmission of food preference test, 3 × Tg-AD mice presented severe deficits in odor-based memory, without gross changes in general odor-ability. Aβ and tau immunoreactivity was not observed in the primary processing regions for odor, the olfactory bulbs (OBs), whereas marked immunostaining was present in the piriform, entorhinal, and orbitofrontal cortex, as well as in the hippocampus. Our results suggest that the impairment in olfactory-based information processing might arise from degenerative mechanisms mostly affecting higher cortical regions and limbic areas, such as the hippocampus.
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