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Related Concept Videos

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
Heart Failure IV: Classification and Diagnostic Evaluation01:30

Heart Failure IV: Classification and Diagnostic Evaluation

Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Rheumatic Heart Disease IV: Nursing Management01:20

Rheumatic Heart Disease IV: Nursing Management

AssessmentA comprehensive assessment is essential in managing a patient with rheumatic heart disease (RHD). Begin with obtaining a detailed medical history, including recent streptococcal infections, a history of rheumatic fever, or previously diagnosed rheumatic heart disease. Assess the patient for symptoms such as fever, chest pain, widespread joint pain (arthralgia), tachycardia, pericardial friction rub, muffled heart sounds, heart murmurs, peripheral edema, subcutaneous nodules, and...

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Related Experiment Video

Updated: May 31, 2026

Induction and Phenotyping of Acute Right Heart Failure in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension
07:41

Induction and Phenotyping of Acute Right Heart Failure in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension

Published on: March 17, 2022

The Romanian Acute Heart Failure Syndromes (RO-AHFS) registry.

Ovidiu Chioncel1, Dragos Vinereanu, Mihai Datcu

  • 1Institute of Emergecy for Cardiovascular Diseases Prof. C.C.Iliescu, Cardiology 1, Bucuresti, Romania. ochioncel@yahoo.co.uk

American Heart Journal
|July 12, 2011
PubMed
Summary

The RO-AHFS registry evaluated acute heart failure syndromes in Romania, revealing significant variations in patient care and outcomes. Key factors influencing mortality included age, arrhythmias, and baseline urea nitrogen levels.

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Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
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Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Published on: February 13, 2021

Related Experiment Videos

Last Updated: May 31, 2026

Induction and Phenotyping of Acute Right Heart Failure in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension
07:41

Induction and Phenotyping of Acute Right Heart Failure in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension

Published on: March 17, 2022

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
09:20

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Published on: February 13, 2021

Area of Science:

  • Cardiology
  • Clinical Research
  • Epidemiology

Background:

  • Acute heart failure syndromes (AHFS) represent a significant cause of hospitalization.
  • Understanding the epidemiology and management of AHFS is crucial for improving patient outcomes.
  • The RO-AHFS registry aimed to provide insights into AHFS in a Romanian population.

Purpose of the Study:

  • To evaluate the epidemiology of AHFS.
  • To assess clinical presentation, inpatient management, and hospital course.
  • To identify predictors of in-hospital mortality in AHFS patients.

Main Methods:

  • A 12-month prospective registry of 3,224 patients hospitalized with AHFS across 13 Romanian centers.
  • Classification of patients into 5 clinical profiles at admission.
  • Multivariate logistic regression analysis to identify independent predictors of in-hospital all-cause mortality (ACM).

Main Results:

  • The cohort (mean age 69.2 years, 56% male) had a mean LVEF of 37.7%.
  • In-hospital ACM was 7.7%, with significant site variation (4.1%-11.0%).
  • Independent risk factors for ACM included age, inotrope therapy, ventricular arrhythmias, and elevated BUN; protective factors were elevated SBP and baseline beta-blocker use.

Conclusions:

  • Substantial variation in AHFS care and outcomes exists among Romanian sites and compared to other European countries.
  • National and regional registries are vital for enhancing patient care.
  • Registries inform the design and execution of global clinical trials for heart failure.