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Related Concept Videos

Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
Proteins: From Genes to Degradation02:11

Proteins: From Genes to Degradation

Within a biological system, the DNA encodes the RNA, and the nucleotide sequence in the RNA further defines the amino acid sequence in the protein. This is referred to as “The Central Dogma of Molecular Biology” - a term coined by Francis Crick.  Central dogma is a firm principle in biology that defines the flow of genetic information within any life form. The two fundamental steps in central dogma are - transcription and translation.
Transcription is the synthesis of RNA molecules by RNA...
Proteins: From Genes to Degradation02:11

Proteins: From Genes to Degradation

Within a biological system, the DNA encodes the RNA, and the nucleotide sequence in the RNA further defines the amino acid sequence in the protein. This is referred to as “The Central Dogma of Molecular Biology” - a term coined by Francis Crick.  Central dogma is a firm principle in biology that defines the flow of genetic information within any life form. The two fundamental steps in central dogma are - transcription and translation.
Transcription is the synthesis of RNA molecules by RNA...

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Related Experiment Video

Updated: May 31, 2026

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
10:37

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Published on: November 15, 2017

The human proteome project: current state and future direction.

Pierre Legrain1, Ruedi Aebersold, Alexander Archakov

  • 1CEA, Life Sciences Division, Fontenay-aux-Roses, France. pierre.legrain@cea.fr

Molecular & Cellular Proteomics : MCP
|July 12, 2011
PubMed
Summary
This summary is machine-generated.

The global Human Proteome Project (HPP) aims to map all human proteins, addressing a gap in current knowledge. This initiative will provide essential protein data and tools to advance biological research and personalized medicine.

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A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
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Last Updated: May 31, 2026

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
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Mass Spectrometry-Based Proteomics Analyses Using the OpenProt Database to Unveil Novel Proteins Translated from Non-Canonical Open Reading Frames
07:38

Mass Spectrometry-Based Proteomics Analyses Using the OpenProt Database to Unveil Novel Proteins Translated from Non-Canonical Open Reading Frames

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A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

Published on: May 22, 2018

Area of Science:

  • Proteomics
  • Genomics
  • Biotechnology

Background:

  • The Human Genome Project mapped human genes, but protein-level evidence is missing for ~30% of genes.
  • Understanding the human proteome is crucial for biological and medical advancements.

Purpose of the Study:

  • To officially launch and outline the global Human Proteome Project (HPP).
  • To systematically map the entire human protein set, including abundance, localization, and function.
  • To establish a comprehensive protein parts list and essential tools for future research.

Main Methods:

  • Utilizing mass spectrometry, antibody capture, and bioinformatics tools.
  • Leveraging ongoing Human Proteome Organization initiatives and a chromosome-centric mapping strategy (C-HPP).

Main Results:

  • The HPP aims to provide protein-level evidence for all human protein-coding genes.
  • It will generate data on protein abundance, distribution, localization, interactions, and functions.
  • The project will stimulate numerous biologically and disease-oriented research projects.

Conclusions:

  • The HPP is essential for completing our understanding of the human proteome.
  • Successful implementation will provide critical resources for protein studies and personalized medicine.
  • Collaboration among funding agencies and the scientific community is urged for HPP participation.