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Updated: May 31, 2026

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models
Published on: December 3, 2019
Herpes simplex virus type 2 seroprevalence and incidence in acute and chronic HIV-1 infection
M Lagnese1, E S Daar, P Christenson
1Division of HIV Medicine and Infectious Diseases at Harbor-UCLA Medical Center, Los Angeles, CA, USA.
Abstract:
Herpes simplex virus type 2 (HSV-2) HIV co-infection is common and associated with increased risk of HIV transmission. HSV-2 seroprevalence was assessed on stored samples from baseline and one year follow-up from 81 patients identified with acute HIV infection and 81 age-matched chronically infected men. HSV-2 seroprevalence at baseline was lower for those with acute rather than chronic HIV-infection, 51.9 versus 71.6% (P = 0.01); relative risk 0.72 (95% confidence interval [CI] 0.57-0.92). Since HSV-2 seroprevalence is lower in those newly HIV-infected, the diagnosis of early HIV infection may allow for counselling to reduce subsequent HSV-2 acquisition.
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Prevalence indicates the proportion of individuals in a population who have a specific disease or health condition at a...

