Related Experiment Video

Updated: May 31, 2026

Chemotherapy-induced Vascular Toxicity - Real-time In vivo Imaging of Vessel Impairment
04:48

Chemotherapy-induced Vascular Toxicity - Real-time In vivo Imaging of Vessel Impairment

Published on: January 7, 2015

Cardiovascular toxicity profiles of vascular-disrupting agents

Ishwaria M Subbiah1, Daniel J Lenihan, Apostolia M Tsimberidou

  • 1Department of Internal Medicine, University of Texas Medical School at Houston, Houston, Texas, USA.

The Oncologist
|July 12, 2011
PubMed
Abstract

Insights

Vascular-disrupting agents (VDAs) show promise in cancer treatment but can cause cardiovascular events. Careful patient selection and cardiology collaboration are crucial for safe VDA use.

Area of Science:

  • Oncology
  • Cardiology
  • Pharmacology

Background:

  • Vascular-disrupting agents (VDAs) target tumor vasculature.
  • Early trials show VDA therapeutic potential but reveal cardiovascular toxicities.

Purpose of the Study:

  • To review preclinical and clinical trial data on VDA-induced cardiovascular events.
  • To characterize the cardiovascular toxicity profile of small-molecule VDAs.

Main Methods:

  • Systematic review of preclinical and Phase I-III clinical trials up to August 2010.
  • Included studies on combretastatin A4 phosphate (CA4P), combretastatin A1 phosphate (CA1P), MPC-6827, ZD6126, AVE8062, and ASA404.

Main Results:

  • Cardiovascular toxicities were reported in Phase I/II trials of CA1P, ASA404, MPC-6827, and CA4P.
  • Common cardiac events included hypertension, tachyarrhythmias, bradyarrhythmias, atrial fibrillation, and myocardial infarction.
  • Cardiac events were dose-limiting in VDA monotherapy and combination trials.

Conclusions:

  • VDAs exhibit a cardiovascular toxicity profile similar to angiogenesis inhibitors.
  • Identifying baseline cardiovascular risk factors is essential for VDA therapy.
  • Collaboration with cardiologists can mitigate VDA toxicity and improve patient outcomes.

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