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The effect Akt2 deletion on tumor development in Pten(+/-) mice

P-Z Xu1, M-L Chen, S-M Jeon

  • 1Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607, USA.

Oncogene
|July 12, 2011
PubMed
Summary

Akt2 deficiency minimally impacts tumor development in Pten(+/-) mice, unlike Akt1. This suggests Akt1 plays a more critical role in inhibiting tumorigenesis across most tissues, with Akt2 showing specific effects in thyroid tumors.

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