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MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder

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Seizure following fluoxetine.

C S Sanjay¹, J P Alexander

¹C.S. Sanjay, MBBS, Junior Resident, Department of Psychiatry, Kasturba Medical College Hospital, Manipal - 576119, Karnataka.

Indian Journal of Psychiatry

|July 12, 2011

Summary

Fluoxetine, rarely linked to seizures, was given to a bipolar patient. This patient experienced generalized tonic clonic seizures after a single dose, prompting a discussion of the implications.

Area of Science:

Neuroscience
Pharmacology
Psychiatry

Background:

Generalized tonic-clonic seizures are a severe neurological event.
Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) antidepressant.
SSRI use has been infrequently associated with seizure induction.

Purpose of the Study:

To report a case of generalized tonic-clonic seizures in a patient with Bipolar Affective Disorder following fluoxetine administration.
To discuss the potential link between fluoxetine and seizure activity in psychiatric patients.

Main Methods:

Case report of a patient with Bipolar Affective Disorder.
Administration of a single dose of fluoxetine.
Observation of seizure development.

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Main Results:

The patient developed generalized tonic-clonic seizures after receiving a single dose of fluoxetine.
This event is notable given the infrequent association of fluoxetine with seizures.

Conclusions:

Fluoxetine may precipitate generalized tonic-clonic seizures in susceptible individuals, such as those with Bipolar Affective Disorder.
Further investigation into the proconvulsant effects of fluoxetine in specific patient populations is warranted.