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Psychiatric complications of chloroquine
1M.S. Bhatia, MD, Reader, Department of Psychiatry, University College of Medical Sciences & Guru Teg Bahadur Hospital, Shahdara, Delhi.
Indian Journal of Psychiatry
|July 12, 2011
Summary
Chloroquine can cause psychiatric issues like psychosis and anxiety, particularly in young females. Symptoms resolved within weeks of stopping the drug.
Area of Science:
- Neuroscience
- Psychiatry
- Pharmacology
Background:
- Chloroquine is an antimalarial and anti-inflammatory drug.
- Psychiatric complications associated with chloroquine are not well-documented.
- Understanding these adverse effects is crucial for patient safety.
Purpose of the Study:
- To report on psychiatric complications induced by chloroquine.
- To identify the most common psychiatric issues and demographic patterns.
- To describe associated symptoms and recovery timelines.
Main Methods:
- Retrospective case series analysis.
- Inclusion of sixty patients with documented chloroquine-induced psychiatric complications.
- Clinical observation and symptom tracking.
Main Results:
- Psychosis was the most frequent complication, followed by anxiety and seizures.
- The highest incidence was observed in patients aged 6-10 years.
- Females constituted 70% of affected patients, with headache and sleeplessness being common symptoms.
Conclusions:
- Chloroquine can precipitate various psychiatric disorders.
- Young females are particularly susceptible to these adverse effects.
- Discontinuation of chloroquine leads to symptom resolution within 2-3 weeks.
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