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Intravascular Delivery of Biologics to the Rat Kidney

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Buprenorphine withdrawal syndrome.

B M Tripathi¹, P Hemaraj, N K Dhar

¹B.M. Tripathi, MD., Additional Professor, Department of Psychiatry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029.

Indian Journal of Psychiatry

|July 12, 2011

Summary

This summary is machine-generated.

Buprenorphine withdrawal symptoms emerge two days after the last dose, peaking on day three and lasting up to ten days. These opiate withdrawal effects are moderate and similar to morphine-type drugs.

Keywords:

buprenorphine morpliine opiate withdrawal

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Area of Science:

Pharmacology
Addiction Medicine
Clinical Research

Background:

Buprenorphine is increasingly used by drug-dependent individuals.
A systematic understanding of buprenorphine withdrawal is needed.

Purpose of the Study:

To investigate the clinical profile of buprenorphine withdrawal.
To characterize the timeline and intensity of withdrawal symptoms.

Main Methods:

Observation of six male parenteral buprenorphine-dependent subjects.
Monitoring opiate withdrawal over a two-week period.

Main Results:

Buprenorphine withdrawal onset occurred 48 hours post-dose.
Withdrawal symptoms peaked around day three.
Symptoms lasted up to ten days.
Withdrawal intensity was moderate and comparable to morphine-type drugs.

Conclusions:

Buprenorphine withdrawal is a distinct clinical event.
The withdrawal profile shares similarities with traditional opioids.
Understanding this profile is crucial for managing buprenorphine dependence.