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Published on: October 4, 2021
Pesistent parkinsonism and tardive dyskinesia
1K.S. Shaji, DPM, MD, Lecturer in Psychiatry, Medical College Hospital, Trichur-680 001, Kerala.
Indian Journal of Psychiatry
|July 12, 2011
Summary
Antipsychotic drugs can cause parkinsonism and tardive dyskinesia. These movement disorders may persist for two years after stopping antipsychotic medication, indicating a potential link.
Area of Science:
- Neuroscience
- Pharmacology
- Movement Disorders
Background:
- Antipsychotic medications are frequently associated with movement disorders.
- Parkinsonism and tardive dyskinesia are known side effects of antipsychotic drug use.
- The long-term persistence of these conditions after drug cessation is not well-characterized.
Purpose of the Study:
- To report the persistence of parkinsonism and tardive dyskinesia.
- To investigate the long-term effects of antipsychotic discontinuation on these movement disorders.
- To discuss the etiological significance of antipsychotic treatment.
Main Methods:
- Case report of patients experiencing parkinsonism and tardive dyskinesia.
- Two-year follow-up period after antipsychotic drug discontinuation.
- Clinical observation and assessment of movement disorder symptoms.
Main Results:
- Both parkinsonism and tardive dyskinesia persisted in patients.
- Symptoms remained evident throughout the entire two-year follow-up period.
- The findings suggest a potentially lasting impact of antipsychotic treatment.
Conclusions:
- Antipsychotic treatment may lead to persistent parkinsonism and tardive dyskinesia.
- Discontinuation of antipsychotic drugs does not always resolve these movement disorders.
- Further research is warranted to understand the mechanisms and long-term implications.
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