Osteitic bone in recalcitrant chronic rhinosinusitis
Related Experiment Video
Updated: May 31, 2026

Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection
Published on: March 14, 2019
W J M Videler1, C Georgalas, D J Menger
1Department of Otorhinolaryngology-Head and Neck Surgery, Academic Medical Centre (AMC), Amsterdam, the Netherlands. W.J.Videler@amc.uva.nl
Introduction:
There is increasing interest in the underlying bone of the paranasal sinuses as an important player in recalcitrant Chronic Rhinosinusitis. Close inspection of CT scans often reveals areas of increased bone density and irregular thickening of the sinus walls. This osteitic bone could at least partly explain, why inflammation of the mucosa persists.
Methods:
We searched PubMed for all relevant studies, using the following text words: chronic rhinosinusitis, sinusitis, bone, osteitis, osteomyelitis, histology, and treatment. Cited references of retrieved articles were also examined.
Results:
Background, available data, potential diagnostic options, treatment implications, and suggestions for future research are discussed.
Conclusion:
Osteitis is associated with CRS, however its role in the pathogenic process is not well defined. More research is needed.
Related Concept Videos
Chronic Pharyngitis
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
Epistaxis
Etiology
Possible causes of this condition include high blood pressure, trauma, low humidity, upper respiratory tract infections, allergies, foreign bodies, nasal inhalation of corticosteroids or illicit drugs, excessive use of decongestant nasal sprays, facial or nasal surgery, anatomic malformation, tumors, or systemic...
Osteoclasts in Bone Remodeling
Tonsillitis II: Management
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
