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Updated: May 31, 2026

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Published on: June 20, 2018
Patient-reported olfactory function following endoscopic sinus surgery with modified endoscopic Lothrop procedure /
J M Yip1, K A Seiberlin, P-J Wormald
1Department of Surgery - Otolaryngology, Head and Neck Surgery, University of Adelaide and Flinders University, The Queen Elizabeth Hospital, Woodville South, South Australia 5011, Australia.
The Modified Endoscopic Lothrop procedure (MELP) improved smell for most patients with chronic frontal sinusitis. This complex surgery, also known as Draf 3, positively impacted subjective olfactory function post-operatively.
Area of Science:
- Otolaryngology
- Neurosurgery
- Rhinology
Background:
- Chronic frontal sinusitis refractory to standard treatments necessitates advanced surgical interventions.
- The Modified Endoscopic Lothrop procedure (MELP), or Draf 3, is a complex surgery for such cases.
- MELP involves drilling the frontal T, potentially impacting olfactory neurons and function.
Purpose of the Study:
- To assess the subjective sense of smell in patients following the Modified Endoscopic Lothrop procedure.
- To evaluate the impact of MELP on olfactory function in patients with refractory chronic frontal sinusitis.
Main Methods:
- Prospective study analyzing retrospective data from 68 patients who underwent MELP between 2003 and 2008.
- Post-operative questionnaires assessed subjective olfactory perception.
- Pre-operative smell assessments and patient records (asthma, nasal polyps, Samter's triad) were reviewed.
Main Results:
- The majority of patients reported improved sense of smell after MELP.
- 39 patients experienced smell improvement, 20 reported no change, and 9 reported worsening.
- No significant correlation was found between olfactory outcomes and asthma, nasal polyps, or Samter's triad.
Conclusions:
- The Modified Endoscopic Lothrop procedure (Draf 3) generally has a positive effect on subjective sense of smell.
- MELP can be an effective treatment for refractory chronic frontal sinusitis with favorable olfactory outcomes.
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