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Updated: May 31, 2026
11:29
Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study
Published on: August 15, 2025
Topiramate related reversible erectile dysfunction in temporal lobe epilepsy
Ling-Chien Hung1, Julie Chi Chow, Chia-Yen Chang
1Department of Neurology, National Cheng Kung University Hospital, 138 Sheng-Li Road, Tainan 704, Taiwan.
Summary
Topiramate (TPM) can cause erectile dysfunction in men, even without other identifiable causes. This sexual side effect resolved after discontinuing the medication, highlighting its potential impact.
Area of Science:
- Neurology
- Pharmacology
- Urology
Background:
- Topiramate (TPM) is an effective antiepileptic drug for epilepsy and migraine.
- Common side effects include somnolence and dizziness.
- Reports on TPM's sexual side effects are rare and inconsistent.
Observation:
- A 31-year-old man experienced erectile dysfunction after several months of TPM use.
- Comprehensive urological and psychiatric evaluations revealed no organic or psychiatric cause.
- Erectile dysfunction symptoms resolved upon cessation of TPM therapy.
Findings:
- This case suggests a potential causal link between Topiramate and erectile dysfunction.
- The temporal relationship between TPM use and symptom onset/resolution was documented.
- No other contributing factors were identified in this patient.
Implications:
- Clinicians should consider erectile dysfunction as a potential adverse effect of Topiramate.
- Further investigation into the neurobiological mechanisms of TPM-induced sexual dysfunction is warranted.
- This finding adds to the understanding of Topiramate's side effect profile in neurological treatments.
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