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Related Experiment Video

Updated: May 31, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Implementing a pharmacist-led sequential antimicrobial therapy strategy: a controlled before-and-after study.

Katherine Dunn¹, Audrey O'Reilly, Bernard Silke

¹Pharmacy Department, St James's Hospital, Dublin, Ireland. katedunn45@yahoo.co.uk

International Journal of Clinical Pharmacy

|July 12, 2011

Summary

This summary is machine-generated.

Implementing guidelines for switching to oral antimicrobials significantly reduced intravenous antimicrobial treatment duration and improved timeliness. This pharmacist-led strategy offers a template for enhancing antimicrobial stewardship and reducing costs.

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Last Updated: May 31, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Area of Science:

Infectious Diseases
Clinical Pharmacy
Health Services Research

Background:

Sequential antimicrobial therapy is key to antimicrobial stewardship.
Improving the switch from intravenous to oral antimicrobials enhances patient care and resource utilization.

Purpose of the Study:

To assess the impact of introducing guidelines and criteria for switching to oral antimicrobials.
To evaluate the effectiveness of a pharmacist-led intervention on antimicrobial treatment duration and timeliness.

Main Methods:

A prospective, controlled before-and-after study was conducted in a 753-bed academic hospital.
An intervention group received drug chart stickers with criteria for switching to oral antimicrobials, while a control group received standard care.
Key outcome measures included duration of intravenous antimicrobial therapy, timeliness of switch, length of stay, and cost savings.

Main Results:

The intervention group showed a significant reduction in the duration of intravenous antimicrobial treatment (P = 0.02) and improved timeliness of switch (P = 0.017) post-intervention.
No significant improvements were observed in the control group.
Antimicrobial costs decreased by a mean of €6.41 per patient in the intervention group.

Conclusions:

Pharmacist-led implementation of guidelines for switching to oral antimicrobials is effective.
This strategy significantly reduces intravenous antimicrobial exposure and improves treatment transition.
The study provides a successful model for other antimicrobial stewardship initiatives.