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Updated: May 31, 2026

Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers
Published on: October 28, 2015
Small mesoporous silica nanoparticles as carriers for enhanced photodynamic therapy
Jie Zhu1, Huixiang Wang, Lei Liao
1Department of Chemistry and Institute of Biomedical Sciences, Fudan University, 220, Handan Road, Shanghai, 200433, China.
Abstract:
Small mesoporous silica nanoparticles (MSNs; ca. 37 nm in diameter) have a high loading capacity for a hydrophobic photosensitizer, SiPcCl(2) (82.6% in weight), and excellent endocytosis properties. As a result, the amount of SiPcCl(2) being delivered to cancer cells is increased by approximately two orders of magnitude compared to pure SiPcCl(2) at the same dosage, and the photodynamic therapy (PDT) efficiency is enhanced by over fourfold. Our method can be widely used to increase the dosage of hydrophobic anti-cancer drugs in cancer cells and therefore increase the cytotoxicity of the drugs.
